What is aloe-emodin?

can be extracted from aloe, soluble in acetaldehyde, benzene, hot ethanol, dilute ammonia water, sodium carbonate and sodium hydroxide solution, easily soluble in hot ethanol, has anti-tumor activity, antibacterial activity, immunosuppression, catharsis, is widely used as drugs, cosmetics raw materials.

Aloe-emodin is the active antibacterial component of rhubarb and can be extracted from aloe vera. Aloe-emodin, a hydroxyanthraquinone, is an active ingredient in aloe leaves and rhubarb roots/rhizomes and has specific activity against neuroectodermal tumors in vitro and in vivo. Anthraquinones belong to a class of tricyclic organic natural compounds with promising anticancer effects. Anthraquinone derivatives possess rich structural diversity and exhibit pleiotropic effects, among which modulation of autophagy appears promising in the context of overcoming resistance to cancer therapy. One of the most promising derivatives in this regard is aloe-emodin.

Aloe-emodin is one of the main components of aloe essential oil. It exists in aloe in a free state or as glycosides in rhubarb, senna and aloe. Those that precipitate from toluene or ethanol are orange-yellow needle-like crystals. Relative molecular mass 270.25. Melting point 223~224 degree . Can sublimate in carbon dioxide gas flow. Easily soluble in hot ethanol, ether and benzene, the solution is yellow, and also soluble in ammonia solution and sulfuric acid, the solution is crimson. The main active ingredients of aloe vera are aloin and aloe-emodin. Aloe vera juice has anti-inflammatory, anti-inflammatory and promotes the healing of damaged skin. Aloe-emodin can inhibit cholesterol absorption, and it can effectively promote intestinal peristalsis, so it has a certain effect in lowering fat and losing weight.

has inhibitory effects on Staphylococcus aureus, Streptococcus aureus, Bacillus diphtheriae, Bacillus subtilis, anthrax, Bacillus paratyphoid, and Shigella dysenteriae. One of its mechanisms of action is to inhibit electron transport in the mitochondrial respiratory chain. Aloe-emodin has a strong inhibitory effect on the nucleic acid and protein synthesis of Staphylococcus aureus, and also has a strong inhibitory effect on common clinical anaerobic bacteria.

Aloe-emodin has strong appetite-increasing and large-intestinal laxative effects. According to foreign medical reports, aloe glycoside is hydrolyzed into aloe-emodin under the action of parasitic bacteria in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall. At the same time, due to the change in osmotic pressure, it is conducive to the elimination of waste in the intestine, thereby achieving irritation. Laxative, this stimulating purgative effect has special effects on constipation and hemorrhoids. Especially for middle-aged and elderly constipation, the therapeutic effect is more obvious.

Abnormal immunity can cause damage to the body. For example, many autoimmune diseases are caused by abnormal expression of autoimmunity and attack normal tissues of the body, causing damage to the body. Aloe-emodin can inhibit the production of antibodies, thereby suppressing immunity. Hyperactive (anti-allergic).

Lipid-lowering and weight-loss effects

Aloe-emodin can inhibit cholesterol absorption, and it can effectively promote intestinal peristalsis, so it has a certain effect in lowering fat and losing weight.

Aloe-emodin can inhibit the production of biological antibodies, inhibit the ability of carbon particles to clear away, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of peritoneal macrophages. In vitro, it has a significant inhibitory effect on the incorporation of [3H]-TDR and [3H]Urd into lymphocytes at a concentration of 100 ug/ml.

Aloe-emodin has strong purgative activity. Intestinal bacteria metabolize aloe-emodin, rhein, and rhein-anthrone, and the latter has strong purgative effect. Clinically used as a laxative, it has the effects of increasing appetite and relieving large intestine. According to foreign medical reports, aloe glycoside is hydrolyzed into aloe-emodin under the action of parasitic bacteria in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall. At the same time, due to the change in osmotic pressure, it is conducive to the elimination of waste in the intestine, thereby achieving irritation. Laxative, this stimulating purgative effect has special effects on constipation and hemorrhoids. Especially for middle-aged and elderly constipation, the therapeutic effect is more obvious.

1. Intermediate of pharmaceutical and chemical industry.

2. Health food additives.

3. Raw materials for cosmetics and hair care.

Research on aloe-emodin

Aloe-emodin derivatives exert anti-atherosclerotic effects by promoting AMBRA1-mediated endothelial cell autophagy), published in the European Journal of Pharmacology. This study reveals the protective effect of aloe-emodin derivatives on atherosclerosis and mechanism.

Aloe-emodin is an anthraquinone compound extracted from the plant Aloe vera. It has a variety of pharmacological activities, including lipid-lowering, anti-diabetic and cardiovascular disease prevention. However, aloe-emodin has poor intestinal absorption, short elimination half-life, and low in vivo bioavailability, which limit its clinical application.

To address these problems, we modified aloe-emodin and replaced the hydroxyl group on the anthracene ring with a succinyl ethyl ester group to obtain a new aloe-emodin derivative. Compared with aloe-emodin, aloe-emodin derivatives have enhanced fat solubility, reduced toxicity, and improved bioavailability.

In this study, we found that aloe-emodin derivatives can reduce endothelial cell damage, inhibit lipid deposition, inflammatory damage and plaque fibrosis, and inhibit the occurrence and development of atherosclerosis. And at the same dose, aloe-emodin derivatives are more effective than aloe-emodin. In terms of mechanism, we found that aloe-emodin derivatives can upregulate the expression of Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) in endothelial cells, promote endothelial cell autophagy, and thereby improve arterial Atherosclerosis.

YTBIO mainly supplies Aloe Emodin powder, etc.Professional Aloe Emodin manufacturers & suppliers.The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,   etc. We always maintain the highest demands on product quality.

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For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 degree , so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

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